2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata

Anu Bahl, and Sanjay Madhukar Jachak, and Kishneth Palaniveloo, and Tulasiramanan R. Ramachandram, and Charles Santhanaraju Vairappan, and Harish Kumar Chopra, (2014) 2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475

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Abstract

A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2 Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

Item Type: Article
Uncontrolled Keywords: 2-Acetoxyverecynarmin C; Briarane diterpenoid; COX-1; COX-2; Pennatula aculeata
Subjects: Q Science > QD Chemistry
Depositing User: MDM FAUZIAH MATSIN
Date Deposited: 15 Dec 2014 07:21
Last Modified: 12 Oct 2017 02:18
URI: http://eprints.ums.edu.my/id/eprint/10150

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