2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata

Anu Bahl, and Sanjay Madhukar Jachak, and Kishneth Palaniveloo, and Tulasiramanan R. Ramachandram, and Charles Santhanaraju Vairappan, and Harish Kumar Chopra, (2014) 2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475

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Abstract

A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2 Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

Item Type:Article
Uncontrolled Keywords:2-Acetoxyverecynarmin C; Briarane diterpenoid; COX-1; COX-2; Pennatula aculeata
Subjects:Q Science > QD Chemistry
ID Code:10150
Deposited By:IR Admin
Deposited On:15 Dec 2014 15:21
Last Modified:12 Feb 2015 16:47

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