Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp

Chin, Soon Phan and Yeaw, Shean Ng and Eun, A Kim and Kishneth Palaniveloo, and Charles Santhanaraju Vairappan, (2015) Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp. Marine Drugs, 13 (5). pp. 3103-3115. ISSN 1660-3397

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Official URL: http://dx.doi.org/10.3390/md13053103

Abstract

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

Item Type:Article
Uncontrolled Keywords:soft coral, Capnella sp., Nephtheidae, sesquiterpenoids, bicyclogermacrene
Subjects:S Agriculture > SH Aquaculture. Fisheries. Angling
Divisions:SCHOOL > Institute for Tropical Biology and Conservation
ID Code:11956
Deposited By:IR Admin
Deposited On:30 Oct 2015 12:26
Last Modified:06 Nov 2015 11:29

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