Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp

Chin, Soon Phan and Yeaw, Shean Ng and Eun, A Kim and Kishneth Palaniveloo, and Charles Santhanaraju Vairappan, (2015) Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp. Marine Drugs, 13 (5). pp. 3103-3115. ISSN 1660-3397

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Abstract

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

Item Type: Article
Uncontrolled Keywords: soft coral, Capnella sp., Nephtheidae, sesquiterpenoids, bicyclogermacrene
Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 30 Oct 2015 04:26
Last Modified: 12 Oct 2017 04:16
URI: http://eprints.ums.edu.my/id/eprint/11956

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