5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

W.A.J.P. Wijesinghe, and Kang, Min Cheol and Lee, Won Woo and Lee, Hyi Seung and Charles S. Vairappan, and Jeon, You-Jin and Takashi Kamada , (2015) 5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages. ALGAE, 29 (4). pp. 333-341.

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Official URL: Http://dx.doi.org/10.4490/algae.2014.29.4.333

Abstract

In this study, four compounds isolated from the red alga Laurencia snackeyi were evaluated for their potential anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These compounds were tested for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. Since -hydroxypalisadin B showed the best activity it was further tested for the production of prostaglandin- (), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the release of pro-inflammatory cytokines tumor necrotic factor-alpha (TNF-), interleukin- (IL-), and interleukin-6 (IL-6). -Hydroxypalisadin B significantly reduced the release and suppressed the iNOS and COX-2 expression in LPS-stimulated RAW 264.7 cells. It also significantly reduced the release of pro-inflammatory cytokines TNF-, IL-, and IL-6. These findings provide the first evidence of anti-inflammatory potential of -hydroxypalisadin B isolated from the red alga L. snackeyi and hence, it could be exploited as an active ingredient in pharmaceutical, nutraceutical and functional food applications.

Item Type:Article
Subjects:Q Science > QD Chemistry
ID Code:12008
Deposited By:IR Admin
Deposited On:20 Oct 2015 13:54
Last Modified:20 Oct 2015 13:54

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