Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp

Phan , Chin Soon and Ng , Shean Yeaw and Kim, Eun A and Jeon, You Jin and Kishneth Palaniveloo , and Charles Santhanaraju Vairappan, (2015) Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp. Marine Drugs, 13 (5). pp. 3103-3115. ISSN 1660-3397

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Official URL: Http://dx.doi.org/10.3390/md13053103

Abstract

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1 ß and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages."

Item Type:Article
Uncontrolled Keywords:soft coral; Capnella sp.; Nephtheidae; sesquiterpenoids; bicyclogermacrene
Subjects:Q Science > Q Science (General)
ID Code:12009
Deposited By:IR Admin
Deposited On:30 Oct 2015 12:16
Last Modified:30 Oct 2015 12:16

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