2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata.

Anu Bahl, and Sanjay M Jachak, and Kishneth Palaniveloo, and Tulasiramanan Ramachandram, and Charles Santhanaraju Vairappan, and Harish K Chopra, (2014) 2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata. Natural Product Communications, 9 (8). 1139-1141 . ISSN 1555-9475

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Official URL: http://www.researchgate.net/publication/265861506_...

Abstract

A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

Item Type:Article
Uncontrolled Keywords:Pennatula aculeata, Briarane diterpenoid, COX-1, COX-2, 2-Acetoxyverecynarmin C.
Subjects:Q Science > QD Chemistry
ID Code:12015
Deposited By:IR Admin
Deposited On:20 Oct 2015 13:52
Last Modified:20 Oct 2015 13:52

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