The effect of carbamazepine on sperm counts in Wistar rats - reflecting upon its mitogenic potential

Shetty, Akhila J. and Narayana, K. and Bairy, K. L. and Bhat, Parvathi and D'Souza , Urban John Arnold (2007) The effect of carbamazepine on sperm counts in Wistar rats - reflecting upon its mitogenic potential. Reproductive Biology, 7 (2). pp. 177-181. ISSN 1642-431X

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Abstract

The present study was aimed to investigate the effects of carbamazepine, an antiepileptic drug, on sperm count in rats. Male Wistar rats were treated with carbamazepine at doses of 9, 18, and 36 mg/kg for five consecutive days. Following the last exposure, on days 14 and 35, spermatozoa were collected from epididymis and counted. On day 14, carbamazepine treatment decreased the sperm number in a dose dependent pattern. On day 35, 9 mg/kg and 36 mg/kg of carbamazepine increased the sperm number in comparison with untreated rats. The results of the study suggest that carbamazepine is a germ cell mitogen.

Item Type:Article
Uncontrolled Keywords:Carbamazepine, Mitogenic factor, Germ cells
Subjects:R Medicine > RG Gynecology and obstetrics
Divisions:SCHOOL > School of Medicine
ID Code:1238
Deposited By:IR Admin
Deposited On:22 Sep 2011 15:05
Last Modified:18 Feb 2015 12:00

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