Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model

Afzan Naquiah Awang and Ju, Lynn Ng and Patricia @ Patricia Clementina Matanjun and Mohd Rosni Sulaiman and Tek, Song Tan and Beng, Yasmin Houi Ooi (2014) Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model. Journal of Applied Phycology, 26 (2). pp. 1043-1048. ISSN 0921-8971


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Obesity has reached epidemic proportions in many countries around the world. Preventing and treating obesity is becoming an increasing priority due to dissatisfaction with high costs and hazardous side effects of anti-obesity drugs. This study was designed to investigate the anti-obesity properties of the Sabah brown seaweed, Sargassum polycystum, on body weight and blood plasma levels of rats fed a high-fat diet supplemented with different doses of the seaweed powder. Male Sprague Dawley rats were divided into five groups, representing control negative (CN) group, control positive (CP) group, low dosage group (LDG), medium dosage group (MDG) and high dosage group (HDG). The study duration was 8 weeks. All groups were fed high-fat diet throughout the study except for CN group, which was fed normal rat chow. LDG, MDG and HDG were supplemented high-fat diet with 2.5, 5.0 and 10.0 % seaweed powder, respectively. By comparing with the CP group, it was found that the HDG (10.0 % seaweed treatment diet) showed the greatest effect in suppressing weight gain, followed by the MDG (5.0 % seaweed treatment diet) and LDG (2.5 % seaweed treatment diet). The HDG decreased the levels of plasma total cholesterol and triglycerides. This finding shows that S. polycystum powder treatment had a positive effect on the inhibition of weight gain and has a promising value in preventing obesity.

Item Type: Article
Uncontrolled Keywords: Sargassum polycystum, Anti-obesity, Cholesterol, Brown seaweed, Sprague Dawley rats
Subjects: T Technology > TX Home economics > Nutrition. Foods and food supply
Divisions: FACULTY > Faculty of Food Science and Nutrition
Depositing User: ADMIN ADMIN
Date Deposited: 07 Jan 2016 05:34
Last Modified: 13 Oct 2017 02:57

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