Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes

Mahsa Motshakeri, and Mahdi Ebrahimi, and Patricia @ Patricia Clementina Matanjun, and Yong , Meng Goh and Suhaila Mohamed, (2013) Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes. Journal of the Science of Food and Agriculture , 93 (7). pp. 1772-1778. ISSN 1097-0010

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Official URL: http://dx.doi.org/10.1002/jsfa.5971

Abstract

BACKGROUND Sargassum polycystum, a brown seaweed, contains various nutrients and bioactive compounds that have antioxidant and healing properties. The research hypothesises that antioxidants and pigments in dietary S. polycystum extracts can improve insulin sensitivity, blood sugar levels and blood lipid levels in a rat model of type 2 diabetes. The diabetes was induced by a high-sugar, high-fat diet for 16 weeks to enhance insulin resistance, followed by a low-dose intraperitoneal injection of streptozotocin (35 mg kg−1 body weight). The doses of S. polycystum tested on diabetic rats were 150 and 300 mg kg−1 body weight for the ethanolic extract or 150 and 300 mg kg−1 for the water extract. Normal rats, untreated diabetic and metformin-treated diabetic rats (n = 6) were used as control. RESULTS Both doses of the alcohol extract of S. polycystum and the 300 mg kg−1 water extract, significantly reduced blood glucose and glycosylated haemoglobin (HbA1C) levels. Serum total cholesterol, triglyceride levels and plasma atherogenic index were significantly decreased after 22 days treatment in all seaweed groups. Unlike metformin, S. polycystum did not significantly change plasma insulin in the rats, but increased the response to insulin. CONCLUSION The consumption of either ethanolic or water extracts of S. polycystum dose dependently reduced dyslipidaemia in type 2 diabetic rats. S. polycystum is a potential insulin sensitiser, for a comestible complementary therapy in the management of type 2 diabetes which can help reduce atherogenic risk.© 2012 Society of Chemical Industry

Item Type:Article
Uncontrolled Keywords:type 2 diabetes, seaweed (Sargassum polycystum), blood glucose, dyslipidaemia, HbA1C, insulin sensitivity
Subjects:T Technology > TX Home economics > Nutrition. Foods and food supply
Divisions:FACULTY > Faculty of Food Science and Nutrition
ID Code:12546
Deposited By:IR Admin
Deposited On:11 May 2016 14:08
Last Modified:11 May 2016 14:08

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