Genome structure and characterisation of an endogenous retrovirus from the zebrafish genome project database

Abtholuddin M. Faris, and Kambol Roziah, (2008) Genome structure and characterisation of an endogenous retrovirus from the zebrafish genome project database. In: 2nd International Conference on Bioinformatics Research and Development, 07-09 July 2008, Vienna, Austria.

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Abstract

A 9.5Kb nucleotide sequence of an endogenous retrovirus was obtained during an attempt to screen a reverse transcriptase-like element in the zebrafish genome project database. The element termed here as ZFERV-2 has the typical genomic organization of a retrovirus in which the LTR flanks the viral genes in this way: LTR-gag-pol-env-LTR. ZFERV-2, resembles a zebrafish endogenous retrovirus, ZFERV discovered previously by Shen and Steiner (2004) and has all the major conserved motifs of the viral genes. In addition, ZFERV-2 has several characteristics possessed by a retrovirus. Firstly, ZFERV-2 shows a replication defective retrovirus because of huge deletion at the protease gene proximal to gag gene is observed. Secondly, an intact genome structure of ZFERV-2 together with 99% sequence similarity on both ends of the LTRs indicate a recent integration into the zebrafish genome. Thirdly, a long leader sequence at 1.5Kb upstream of the viral genes and a large genome size are characteristics shared by retroviruses isolated from lower vertebrates.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Uncontrolled Keywords: Endogenous retrovirus, Genome, Reverse transcriptase, Piscine
Subjects: ?? QH426-470 ??
Divisions: SCHOOL > School of Science and Technology
Depositing User: ADMIN ADMIN
Date Deposited: 04 Sep 2018 00:59
Last Modified: 04 Sep 2018 00:59
URI: http://eprints.ums.edu.my/id/eprint/1275

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