Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Caillaud, Amandine and de la Iglesia, Pablo and Campàs, Mònica and Elandaloussi, Laurence M and Fernández, M and Normawaty Mohamad Noor, and Andree, Karl B. and Diogène, Jorge (2010) Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia. Toxicon, 55 (2-3). pp. 633-637. ISSN 0041-0101

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Abstract

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.

Item Type: Article
Uncontrolled Keywords: Prorocentrum rhathymum; Protein phosphatase inhibition assay; Neuroblastoma cell-based assay; LC-MS/MS; Okadaic acid
Subjects: Q Science > QK Botany
Divisions: SCHOOL > Borneo Marine Research Institute
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 24 Jan 2011 09:14
Last Modified: 19 Oct 2017 02:37
URI: http://eprints.ums.edu.my/id/eprint/1347

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