Chemical profiling and biological activities of sponges from Kudat

Premila Mohan, (2010) Chemical profiling and biological activities of sponges from Kudat. Universiti Malaysia Sabah. (Unpublished)


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Sponges are marine living invertebrates and they are denoted as one of the few primary producers of natural products in the ocean. These organisms are well-known filter . feeders and they are classified under the phylum Porifera. This project studied on the chemical profiling as well as biological activities of the sponges. There were altogether five samples of sponges studied (51-Haliclona sp., S2-Phyllospongia sp., 53- Phyllospongia lamellose, S4-Stylotella aurantium and 55-Aka sp.). The percentage of fractions obtained from the sponges were 0.12% of methanol fraction and 0.11% of hexane fraction for Sample 1, 0.21% of methanol fraction and 0.14% of hexane fraction for Sample 2, 0.32% of methanol fraction and 0.42% of hexane fraction for Sample 3, 0.15% of methanol fraction and 0.13% of hexane fraction for Sample 4 and 0.09% of methanol fraction and 0.07% of hexane fraction for Sample 5. The yield of fractions for the studied sponges displayed prominent bioactive properties by inhibiting the growth of pathogenic bacteria, leading to the isolation of one part of the compound from the methanol fraction of Sample 5. Due to limited information obtained during the study, the structures of the compounds were not elucidated. Research and several studies on marine natural products show antimicrobial defense of marine living organism towards the environment. The marine natural products are not only important for the purpose of research, but also to contribute to the field of biotechnology and biomedicine.

Item Type: Academic Exercise
Uncontrolled Keywords: Sesquiterpene , Alkaloid , Terpene , cytotoxic ,Preparative Thin Layer Chromatography (PTLC)
Subjects: Q Science > QH Natural history > QH301 Biology
Depositing User: Unnamed user with email
Date Deposited: 22 Jun 2016 06:40
Last Modified: 01 Nov 2017 07:09

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