Yeast glycogen synthase kinase-3 beta pathway inhibitors from an organic extract of streptomyces sp.

Sarot, Cheenpracha and Zhang , Hui and Annie M. N. Mar, and Adam P. Foss, and Foo, Sek Hin and Lai, Ngit Shin and Jee, Jap Meng and Seow, Heng Fong and Ho , Coy Choke and Chang, Leng Chee (2009) Yeast glycogen synthase kinase-3 beta pathway inhibitors from an organic extract of streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

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Official URL: http://dx.doi.org/10.1021/np900163f

Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2'-(phenylacetyl)propanimide (5), and 2-amino-N-(2'-(cyclohex-2 ''-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-alpha-rhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, (1)H and (13)C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 beta assay.

Item Type:Article
Uncontrolled Keywords:Cycloheximide, Kinase, Ring
Subjects:?? QK504-(638) ??
Divisions:SCHOOL > School of Science and Technology
ID Code:1365
Deposited By:IR Admin
Deposited On:16 Aug 2011 15:28
Last Modified:24 Feb 2015 11:28

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