Yeast glycogen synthase kinase-3 beta pathway inhibitors from an organic extract of streptomyces sp.

Sarot, Cheenpracha and Zhang, Hui and Annie M. N. Mar, and Adam P. Foss, and Foo, Sek Hin and Lai, Ngit Shin and Jee, Jap Meng and Seow, Heng Fong and Ho, Coy Choke and Chang, Leng Chee (2009) Yeast glycogen synthase kinase-3 beta pathway inhibitors from an organic extract of streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

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Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2'-(phenylacetyl)propanimide (5), and 2-amino-N-(2'-(cyclohex-2 ''-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-alpha-rhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, (1)H and (13)C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 beta assay.

Item Type: Article
Uncontrolled Keywords: Cycloheximide, Kinase, Ring
Subjects: ?? QK504-(638) ??
Divisions: SCHOOL > School of Science and Technology
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 16 Aug 2011 07:28
Last Modified: 19 Oct 2017 02:42
URI: http://eprints.ums.edu.my/id/eprint/1365

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