Three new amides from Streptomyces sp H7372

Sarot, Cheenpracha and Robert, P. Barris and Tammy, T. Tran and Jap, Meng Jee and Heng, Fong Seow and Cheah, Hwen Yee and Ho, Coy Choke and Leng, Chee Chang (2011) Three new amides from Streptomyces sp H7372. Journal of the Brazilian Chemical Society, 22 (2). pp. 223-229. ISSN 0103-5053

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Official URL: http://dx.doi.org/10.1590/S0103-50532011000200006

Abstract

Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-beta-D-glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(Delta Ala-L-Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two-hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His(-) and inactive on SD His(+) at 2.5 mu g per disk, respectively.

Item Type:Article
Uncontrolled Keywords:Streptomyces sp., Yeast two-hybrid screen, Ras-Raf-1 interaction, Amides, Cyclo(Delta Ala-L-Val)
Subjects:?? QR1-74.5 ??
Divisions:SCHOOL > School of Science and Technology
ID Code:1448
Deposited By:IR Admin
Deposited On:08 Aug 2011 16:10
Last Modified:16 Feb 2015 15:42

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