Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry method

Muhammad Aqeel Ashraf , and Bin , Zheng and Gaoyang , Xing and Ye , Bi and Guodong , Yan and Jing , Wang and Yingkun , Cheng and Yan , Liu and Jing , Xie (2016) Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry method. Saudi Journal of Biological Sciences, 23 (1). pp. 54-65. ISSN 1319-562X

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Official URL: http://dx.doi.org/10.1016/j.sjbs.2015.08.009

Abstract

As a novel oral drug delivery system, proliposome was applied to improve the solubility of active components of Ginkgo biloba extract (GbE). There are currently few reports focusing on the pharmacokinetic characteristics of proliposome of GbE (GbP). A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous quantification of active components of GbP and a commercial tablet product (Ginaton) in rat plasma was developed and successfully validated. The method was applied to the comparative pharmacokinetic evaluation of GbP and Ginaton in rat plasma. The results indicated that GbP has a significant effect on absorption, elimination and bioavailability of flavonoids and terpenoid lactones in comparison with Ginaton. The obtained results would be helpful for evaluating the absorption mechanism in the gastrointestinal tract in pharmacokinetic level and guiding the development of the novel oral drug delivery system.

Item Type:Article
Uncontrolled Keywords:Ginkgo biloba extract, Pharmacokinetics, Proliposome, Ultra performance liquid chromatography–tandem mass spectrometry
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:FACULTY > Faculty of Science and Natural Resources
ID Code:14800
Deposited By:IR Admin
Deposited On:26 Oct 2016 14:02
Last Modified:26 Oct 2016 14:02

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