Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol

Mariani Rajin, and A H Kamaruddin, (2016) Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol. In: International Conference on Chemical Engineering and Bioprocess Engineering, 25-26 October 2016, Jeddah, Saudi Arabia .

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Official URL: http://dx.doi.org/10.1088/1755-1315/36/1/012061

Abstract

Thermodynamic studies of free Candida antartica lipase B in kinetic resolution of acebutolol have been carried out to characterize the temperature effects towards enzyme stability and activity. A decreased in reaction rate was observed in temperature above 40oC. Thermodynamic studies on lipase deactivation exhibited a first-order kinetic pattern. The activation and deactivation energies were 39.63 kJ/mol and 54.90 kJ/mol, respectively. The enthalpy and entropy of the lipase deactivation were found to be 52.12 kJ/mol and -0.18 kJ/mol, respectively.

Item Type:Conference Paper (UNSPECIFIED)
Uncontrolled Keywords:Thermodynamic, Candida antartica, kinetic resolution, acebutolol
Subjects:Q Science > QC Physics
Divisions:FACULTY > Faculty of Engineering
ID Code:15486
Deposited By:Munira M
Deposited On:02 Feb 2017 13:47
Last Modified:02 Feb 2017 13:47

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