Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol

Mariani Rajin, and A H Kamaruddin, (2016) Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol. In: International Conference on Chemical Engineering and Bioprocess Engineering, 25-26 October 2016, Jeddah, Saudi Arabia.

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Abstract

Thermodynamic studies of free Candida antartica lipase B in kinetic resolution of acebutolol have been carried out to characterize the temperature effects towards enzyme stability and activity. A decreased in reaction rate was observed in temperature above 40oC. Thermodynamic studies on lipase deactivation exhibited a first-order kinetic pattern. The activation and deactivation energies were 39.63 kJ/mol and 54.90 kJ/mol, respectively. The enthalpy and entropy of the lipase deactivation were found to be 52.12 kJ/mol and -0.18 kJ/mol, respectively.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Uncontrolled Keywords: Thermodynamic, Candida antartica, kinetic resolution, acebutolol
Subjects: Q Science > QC Physics
Divisions: FACULTY > Faculty of Engineering
Depositing User: Users 83 not found.
Date Deposited: 02 Feb 2017 05:47
Last Modified: 12 Oct 2017 02:35
URI: http://eprints.ums.edu.my/id/eprint/15486

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