The relationship between plasma glucose in oral glucose tolerance test and HbA1c in Queen Elizabeth Hospital Kota Kinabalu

Siti Khadzirah Daud, (2015) The relationship between plasma glucose in oral glucose tolerance test and HbA1c in Queen Elizabeth Hospital Kota Kinabalu. Masters thesis, Universiti Malaysia Sabah.

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Abstract

The blood glucose level measurement is important in the diagnosis of Diabetes mellitus. As recommended by the World Health Organisation (WHO) in 1955, fasting plasma glucose (FPG) level of > 7.S mmol/L (140 mg/dL) and/or 2-hour post-glucose loading (or random plasma glucose) level of >11.1 mmol/L (200mg/dL) in Oral Gluose Tolerance Test (OGlT) are used as diagnostic criteria. Both tests are commonly used to diagnose those at risk of Type 2 Diabetes mellitus. However, recently, WHO has recommended that Hemoglobin Ale (HbAlc) with cutoff point of >6.5% can be used as a diagnostic test for Diabetes mellitus. Hence, this study was undertaken to determine whether the recommendation applies to the patient population in Queen Elizabeth Hospital Kota Kinabalu. The fasting plasma glucose and 2-hour post-glucose loading test were performed using Roche Chemistry Analyzer Modular PSOO while for the HbAle test was estimated using the PDQ Primus Plus HbAle analyzer at the Department of Pathology, Queen Elizabeth Hospital. The data were analyzed and interpreted using the Statistical Package for The Social Sciences (SPSS) Version lS.0. There was a strong correlation between FPG test and HbAle test. Similarly, there was a strong correlation between 2-hour post-glucose loading test and HbAlc . In conclusion, there is a strong correlation between FPG, 2-hour post-glucose loading in Oral Glucose Tolerance Test (OGTI) and HbAlc. Hence, HbAle can be used as the diagnostic criteria with the cut-off point of 6.7% in Queen Elizabeth Hospital, Kota Kinabalu.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Blood glucose , diagnostic , Queen Elizabeth Hospital , Kota Kinabalu
Subjects: R Medicine > RC Internal medicine
Divisions: SCHOOL > School of Medicine
Depositing User: Noraini
Date Deposited: 22 Mar 2018 02:02
Last Modified: 22 Mar 2018 02:02
URI: http://eprints.ums.edu.my/id/eprint/19500

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