Chemical diversity and biological activities of Halogenated metabolites from Red Algae Genus Laurencia from Carrington Reef

Toh, Denise Yew Leng (2006) Chemical diversity and biological activities of Halogenated metabolites from Red Algae Genus Laurencia from Carrington Reef. Universiti Malaysia Sabah. (Unpublished)

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Abstract

This study was carried out on 5 Laurencia species. They are Laurencia snackeyi, Laurencia nangii, Laurencia sp., Laurencia papilose, and Laurencia cribb. Five halogenated secondary metabolites were isolated from L. snackeyi. The halogenated secondary metabolites are (2Z., 6S·, 9R·)-chamigr-2, 5(I4)-dien-8-one (80), Palisadin B (76), 5-acetoxypalisadin B (7), Aplysistatin (6), and 5f3-hydroxypalisadin B (81). The halogenated secondary metabolites were then tested against marine environmental bacteria, human pathogenic bacteria and yeast. (2Z., 6S·, 9R·)chamigr- 2, 5(l4)-dien-8-one (80) and Palisadin B (76) did not show any positive activity against aU of them 5-acetoxypalisadin B (7) and Aplysistatin (6) showed positive activity against 5 marine environmental bacteria which were Clostridium cellobioparum, Clostridium sordelli, Clostridium novyi, Vibrio arginolyticus and Vibrio parahaemolyticus. 5f3-hydroxypalisadin B (81) showed positive activity against 2 marine environmental bacteria which were Clostridium sordelli and Vibrio parahaemolyticus, 2 human pathogenic bacteria Vibrio chlolera and E. coli, and 2 different strains of Candida albicans yeast.

Item Type: Academic Exercise
Uncontrolled Keywords: Laurencia species , marine environmental bacteria , human pathogenic bacteria
Subjects: Q Science > QH Natural history
Divisions: SCHOOL > School of Science and Technology
Depositing User: Noraini
Date Deposited: 04 Jun 2018 00:18
Last Modified: 04 Jun 2018 00:18
URI: http://eprints.ums.edu.my/id/eprint/20131

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