A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats

Yasumasa, Okazaki and Iqbal, Mohammad and Norito, Kawakami and Yorihiro, Yamamoto and Shinya Y., Toyokuni and Shigeru, Okada (2010) A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. Journal of Clinical Biochemistry and Nutrition, 47 (3). pp. 198-207. ISSN 0912-0009

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Official URL: http://dx.doi.org/10.3164/jcbn.10-52

Abstract

It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the antioxidative effect of a beverage obtained via citric acid fermentation of black soybean (BBS), using a rat model of renal oxidative injury induced by a renal carcinogen, ferric nitrilotriacetate. BBS (10 ml/kg) was orally administered 30 min before ferric nitrilotriacetate treatment. Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2′-deoxyguanosine. Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats. Elevation of serum creatinine and urea nitrogen was significantly suppressed in the BBS-pretreated rats. These data suggest that dietary intake of BBS is useful for the prevention of renal tubular oxidative damage mediate by iron, and warrant further investigation.

Item Type:Article
Uncontrolled Keywords:Black soybean, anthocyanin, ferric nitrilotriacetate, oxidative stress, lipid peroxidation
Subjects:?? TP500-660 ??
Divisions:SCHOOL > Biotechnology Research Institute (BRI)
ID Code:2139
Deposited By:IR Admin
Deposited On:09 Mar 2011 17:31
Last Modified:17 Feb 2015 16:24

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