Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol

Mariani Rajin, and A H Kamaruddin, (2016) Effect of temperature on Candida antartica lipase B activity in the kinetic resolution of acebutolol. IOP Conference Series: Earth and Environmental Science, 36 (1). pp. 12-61.

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Abstract

Thermodynamic studies of free Candida antartica lipase B in kinetic resolution of acebutolol have been carried out to characterize the temperature effects towards enzyme stability and activity. A decreased in reaction rate was observed in temperature above 40oC. Thermodynamic studies on lipase deactivation exhibited a first-order kinetic pattern. The activation and deactivation energies were 39.63 kJ/mol and 54.90 kJ/mol, respectively. The enthalpy and entropy of the lipase deactivation were found to be 52.12 kJ/mol and -0.18 kJ/mol, respectively.

Item Type: Article
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: FACULTY > Faculty of Engineering
Depositing User: MR OTHMAN HJ RAWI
Date Deposited: 15 Mar 2019 07:21
Last Modified: 15 Mar 2019 07:21
URI: http://eprints.ums.edu.my/id/eprint/21629

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