Sponges from North Borneo and their bioactivity against human colorectal cancer cells

Yoong, Soon Yong and Swee, Cheng Lim and Lee, Ping Chin and Yee, Soon Ling (2018) Sponges from North Borneo and their bioactivity against human colorectal cancer cells. Borneo Journal of Marine Science and Aquaculture, 2. pp. 40-47. ISSN 2600-8637

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Abstract

Sponges are major source of numerous cytotoxic compounds that are used for defence as well as adaptation to the environment. Numerous studies have discovered compounds from sponge extracts that were effective against a wide range of cancer cells. In this study, a total of 23 sponges comprising of 19 species were collected from Northeast Borneo. Sponges were treated and extracted using modified Folch extraction method, followed by cytotoxicity assay to determine their effectiveness against different colorectal cancer cells. Our results demonstrate that Monanchora clathrata, Dysidea sp., and Jaspis sp. possess different degrees of cytotoxicity against a wide range of human colorectal cancer cells. Monanchora clathrata (KDT07), Dysidea sp. (KDT09), and Jaspis sp. (KDT18) are among the demosponges which possess significant cytotoxicity against colorectal cancer cell lines, including HCT116, LoVo, SW480, and SW620. KDT08 and KDT21 which fall under the same genus Dysidea, possess insignificant cytotoxicity against colorectal cancer cells suggested environmental factors (symbiotic organisms) play a role in biosynthesizing bioactive compounds. Presented results suggested the importance of intensifying research on isolating and purifying natural products from marine sponges for useful applications.

Item Type: Article
Uncontrolled Keywords: Marine sponges, Demosponges, Northeast Borneo, Bioactivity, Cell viability
Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling
Divisions: SCHOOL > Borneo Marine Research Institute
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 25 Apr 2019 23:28
Last Modified: 25 Apr 2019 23:28
URI: http://eprints.ums.edu.my/id/eprint/21865

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