Enrichment, in vitro, and quantification study of antidiabetic compounds from neglected weed Mimosa pudica using supercritical CO2 and CO2-Soxhlet

Tasnuva Sarwar Tunna, and Sarker, Md Zaidul Islam, and Ghafoor, Kashif, and Ferdosh, Sahena, and Jaffri, Juliana Md, and Al-Juhaimi, Fahad Y, and Selamat, Jinap, and Ali, Md Eaqub, and Md Jahurul Haque Akanda, and Awal, Md Shihabul, and Ahmed, Qamar Uddin, (2017) Enrichment, in vitro, and quantification study of antidiabetic compounds from neglected weed Mimosa pudica using supercritical CO2 and CO2-Soxhlet. Journal Separation Science and Technology, 53 (2). pp. 243-260.

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Abstract

Supercritical fluid extraction (SFE) using carbon dioxide (CO2) and liquid CO2 using Soxhlet (CO2-Soxhlet) extraction were employed to extract three (3) antidiabetic compounds viz. stigmasterol, quercetin, and avicularin from Mimosa pudica. Various extraction parameters were studied. Extracts were analyzed pharmacologically, qualitatively and quantitatively to ascertain enrichment levels. All three antidiabetic compounds were effectively enriched under optimized conditions of temperature 60°C, pressure 40 MPa, co-solvent ratio 30%, and CO2 flow rate of 5 ml min−1. SFE was found to be the better method for enrichment of the antidiabetic compounds than the CO2-Soxhlet method. Extraction conditions were seen to affect the enrichment of desired compounds.

Item Type: Article
Uncontrolled Keywords: Mimosa pudica, supercritical fluid extraction (SFE), CO2-Soxhlet, antidiabetic compounds, α-glucosidase assay
Subjects: Q Science > QK Botany
Divisions: FACULTY > Faculty of Food Science and Nutrition
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 01 Oct 2019 06:27
Last Modified: 01 Oct 2019 06:27
URI: http://eprints.ums.edu.my/id/eprint/23697

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