C-15 halogenated acetogenin with antibacterial activity against food pathogens

Charles Santhanaraju Vairappan, and Tan, Kai Lee (2009) C-15 halogenated acetogenin with antibacterial activity against food pathogens. Malaysian Journal of Science, 28 (3). pp. 263-268. ISSN 1394-3065

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Abstract

As part of our continuous effort in search of bioactive secondary metabolites from marine organisms, we studied a specimen of red algae, Laurencia nangii Masuda from Banggi Island, Kudat District, Sabah. One C-15 acetogenin was isolated and identified as Z-dihydrorhodophytin (1, 15%). This compound showed 100% inhibition against the tested bacteria at 30 μgdisc-1. MIC values for Salmonella enteritidis, Vibrio cholerae and Staphalococcus aereus were 1.25 μgdisc-1, 2.25 μgdisc-1 and 2.25 μgdisc-1, respectively ; while Escherichia coli, Salmonella typhii and Salmonella thphymunium were inhibited at MIC value of 7.25 μgdisc -1. This study showed that Z-dihydrorhodophytin (1) has significant antibacterial activity against the tested food pathogens and may have potential to be used as lead pharmaceutical drug candidate in combating "antibiotic resistant bacteria".

Item Type: Article
Uncontrolled Keywords: Antibiotic resistant bacteria, C15-acetogenin, Laurencia nangii
Subjects: Q Science > QR Microbiology > QR75-99.5 Bacteria
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Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 21 Mar 2011 11:09
Last Modified: 13 Oct 2017 02:54
URI: http://eprints.ums.edu.my/id/eprint/2481

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