Role of Immunopathology in Clinical Course of Malaria: A Review

Aye Aye Wynn, and Ohnmar Myint, (2018) Role of Immunopathology in Clinical Course of Malaria: A Review. Borneo Journal of Medical Sciences, 12 (3). pp. 1-10. ISSN 1985-1758

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Abstract

Malaria is a major health problem in various parts of the world especially affecting the tropical countries. It affects the vital organs causing severe complicated malaria. Clinical syndromes like severe cerebral anaemia, coagulation abnormalities, respiratory distress and severe anaemia can increase the mortality of malaria infected cases. Variation in individual susceptibility and severity and type of clinical presentations of malaria raises the need for study of both the parasite and host immune reactions as well as the contribution of inflammatory cytokines in malaria pathogenesis. This study explored the immunopathological basis and advances of severe malaria and their importance in pathogenesis of malaria and its complications. Previous and ongoing studies indicate that changes in endothelium during the sequestration of parasites in organs causes disruption of endothelial barrier function leading to serious effects of malaria. Parasite and host factors contribute to disturbance of cytokine regulation and escape of parasites from the immune system of the host. Immunopathological changes and dysregulation of cytokine production play central role in pathogenesis and disease severity in malaria.

Item Type: Article
Uncontrolled Keywords: malaria, immunopathology, host, parasites
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: FACULTY > Faculty of Medicine and Health Sciences
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 11 Mar 2020 06:13
Last Modified: 18 Jun 2020 14:50
URI: http://eprints.ums.edu.my/id/eprint/25172

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