Cytotoxic sesquiterpenoids from soft coral Capnella imbricata

Phan, Chin Soon and Takashi Kamada, and Takahiro Ishii, and Toshiyuki Hamada, and Charles Santhanaraju Vairappan, (2019) Cytotoxic sesquiterpenoids from soft coral Capnella imbricata. Natural Product Communications. pp. 1-4.

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Abstract

A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry. Capgermacrene A (2) showed potent cytotoxicity against adult T-cell leukemia, S1T cells at half-maximal inhibitory concentration of 0.79 µg/mL.

Item Type: Article
Uncontrolled Keywords: Capnella, soft coral, sesquiterpene, capgermacrene H, cytotoxicity, adult T-cell leukemia
Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 02 Jun 2020 08:55
Last Modified: 02 Jun 2020 08:55
URI: http://eprints.ums.edu.my/id/eprint/25474

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