Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis

Phan, Chin-Soon and Yee, Chun-Sieng and Charles Santhanaraju Vairappan, and Takahiro Ishii, and Takashi Kamada, (2019) Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis. Chemistry of Natural Compounds, 55. pp. 285-288.

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Abstract

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A−K (1−11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 μM, respectively.

Item Type: Article
Uncontrolled Keywords: Sinularia flexibilis, soft coral, diterpenoid, cembrane, antifungal
Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 02 Jun 2020 08:58
Last Modified: 02 Jun 2020 08:58
URI: http://eprints.ums.edu.my/id/eprint/25477

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