Two new clerodane-type diterpenoids from Bornean liverwort Gottschelia schizopleura and their cytotoxic activity

Ng, Shean Yeaw and Takashi Kamada and Monica Suleiman and Charles Santhanaraju Vairappan (2018) Two new clerodane-type diterpenoids from Bornean liverwort Gottschelia schizopleura and their cytotoxic activity. Natural Product Research, 32 (15). pp. 1832-1837.

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Abstract

The Bornean liverwort Gottschelia schizopleura was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of G. schizopleura through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds 1–6 were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound 1 and 2 showed active inhibition against HL-60 and B16-F10 cells.

Item Type: Article
Uncontrolled Keywords: Clerodane diterpenoids, Gottschelia schizopleura, Jungermanniaceae, liverwort, Borneo, cytotoxic activity
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: SITI AZIZAH BINTI IDRIS -
Date Deposited: 01 Jul 2020 03:12
Last Modified: 01 Jul 2020 03:12
URI: http://eprints.ums.edu.my/id/eprint/25553

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