α-glucosidase inhibitors isolated from Mimosa pudica L.

Tasnuva ST, and Qamar UA, and Ghafoor, Kashif, and F. Sahena, and Md Jahurul Haque Akanda, and A. H. Rukshana, and M.J.Juliana, and Fahad Y. Al-Jalifah, and K. C. A. Jalal, and Md.Eaqub Ali, and I.S.M. Zaidul, (2019) α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 33 (10). pp. 1495-1499.

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Abstract

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.

Item Type: Article
Uncontrolled Keywords: Fabaceae, α-glucosidase inhibitors.
Subjects: Q Science > Q Science (General)
T Technology > TP Chemical technology > TP368-456 Food processing and manufacture
Divisions: FACULTY > Faculty of Food Science and Nutrition
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 25 Aug 2020 03:10
Last Modified: 25 Aug 2020 03:10
URI: http://eprints.ums.edu.my/id/eprint/25847

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