Antibacterial activity of fine chemicals from Scenedesmus acuminatus (Scenedesmaceae, Chlorococcales, Chlorophyta)

Charles Santhanaraju Vairappan, and Nie, Goh Pei and Yen, Ang May (2007) Antibacterial activity of fine chemicals from Scenedesmus acuminatus (Scenedesmaceae, Chlorococcales, Chlorophyta). Malaysian Journal of Science, 26 (1). pp. 65-72. ISSN 1394-3065


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Microalgae, Scenedesmus acuminatus was batch-cultured in a photo-bioreactor to facilitate better culture control and higher productivity. Each batch was cultured for 100 hours; final cell density and specific growth rate were 5.0 × 10⁷ cell/ml and 0.028 hour¯¹, respectively. The harvested biomass produced 70.80 mg crude extract with antibacterial activities. Bioassay guided separation and spectroscopy data revealed a mixture of fatty acid methyl esters (FAME) (C16:0, C16:1, C18:1n9c, C18:2n6c and C20:0) as the active principal. Further antibacterial bioassay with commercially available individual FAME revealed C18:1n9c methyl ester and C18:2n6c methyl ester, as the active compounds in the mixture. The active methyl esters, C18:1n9c and C18:2n6c, inhibited 48% (MIC: 0.3 μgdisc¯¹) and 100% (MIC: 0.3 and 1.0 μgdisc¯¹) of tested bacteria, respectively.

Item Type:Article
Uncontrolled Keywords:Antibacterial activity, FAME, Microalgae, Scenedesmus acuminatus
Subjects:Q Science > QR Microbiology
Divisions:SCHOOL > Institute for Tropical Biology and Conservation
ID Code:3729
Deposited By:IR Admin
Deposited On:19 Mar 2012 10:03
Last Modified:18 Feb 2015 12:03

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