Biological activity of carbazole alkaloids and essential oil of murraya koenigii against antibiotic resistant microbes and cancer cell lines

Nagappan, Thilahgavani and Ramasamy, Perumal and Mohd Effendy Abdul Wahid, and Segaran, Thirukanthan Chandra and Charles Santhanaraju Vairappan, (2011) Biological activity of carbazole alkaloids and essential oil of murraya koenigii against antibiotic resistant microbes and cancer cell lines. Molecules, 11 (16). pp. 9651-9664. ISSN 1420-3049

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Official URL: http://dx.doi.org/10.3390/molecules16119651

Abstract

A total of three carbazole alkaloids and essential oil from the leaves of Murraya koenigii (Rutaceae) were obtained and examined for their effects on the growth of five antibiotic resistant pathogenic bacteria and three tumor cell lines (MCF-7, P 388 and Hela). The structures of these carbazoles were elucidated based on spectroscopy data and compared with literature data, hence, were identified as mahanine (1), mahanimbicine (2) and mahanimbine (3). The chemical constituents of the essential oil were identified using Gas Chromatography-Mass Spectroscopy (GCMS). These compounds exhibited potent inhibition against antibiotic resistant bacteria such as Staphylococcus aureus (210P JTU), Psedomonas aeruginosa (ATCC 25619), Klebsiella pneumonia (SR1-TU), Escherchia coli (NI23 JTU) and Streptococcus pneumoniae (SR16677-PRSP) with significant minimum inhibition concentration (MIC) values (25.0-175.0 mg/mL) and minimum bacteriacidal concentrations (MBC) (100.0-500.0 μmg/mL). The isolated compounds showed significant antitumor activity against MCF-7, Hela and P388 cell lines. Mahanimbine (3) and essential oil in particular showed potent antibacteria and cytotoxic effect with dose dependent trends (≤5.0 μg/mL). The findings from this investigation are the first report of carbazole alkaloids' potential against antibiotic resistant clinical bacteria, MCF-7 and P388 cell lines.

Item Type:Article
Uncontrolled Keywords:Antibiotic resistant, Cancer cell lines, Carbazole alkaloids, Murraya koenigii, Pathogenic bacteria
Subjects:?? RC254-282 ??
Divisions:SCHOOL > School of Medicine
ID Code:4862
Deposited By:IR Admin
Deposited On:12 Sep 2012 08:41
Last Modified:16 Feb 2015 11:23

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