Evaluation of chromosomal alteration in electrical workers occupationally exposed to low frequency of electro magnetic field (EMFs) in coimbatore population, India

Balasubramanian Balamuralikrishnan, and Vellingiri Balachandar, and Shanmugam Suresh Kumar, and Nattan Stalin, and Prakash Varsha, and Subramaniam Mohana Devi, and Meyyazhagan Arun, and Pappuswamy Manikantan, and Chinnakulandhai Venkatesan, and Keshavarao Sasikala, and Shahnaz N Dharwadkar, (2013) Evaluation of chromosomal alteration in electrical workers occupationally exposed to low frequency of electro magnetic field (EMFs) in coimbatore population, India. In: Evaluation of chromosomal alteration in electrical workers occupationally exposed to low frequency of electro magnetic field (EMFs) in coimbatore population, India.

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Official URL: http://dx.doi.org/10.7314/APJCP.2012.13.6.2961

Abstract

Extremely low frequency electro magnetic fields (EMFs) have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer. An increased number of chromosomal alterations in peripheral lymphocytes are correlated with elevated incidence of cancer. The aim of the present study was to assess occupationally induced chromosomal damage in EMF workers exposed to low levels of radiation. We used conventional metaphase chromosome aberration (CA) analysis and the micronucleus (MN) assay as biological indicators of non ionizing radiation exposure. In the present study totally 70 subjects were selected including 50 exposed and 20 controls. Informed written consent was obtained from all participants and the study was performed in accordance with the Declaration of Helsinki and the approval of the local ethical committee. A higher degree of CA and MN was observed in exposed subjects compared to controls, the frequency of CA being significantly enhanced with long years of exposure (P<0.05). Moreover increase in CA and MN with age was noted in both exposed subjects and controls, but was significantly greater in the former. The results of this study demonstrated that a significant induction of cytogenetic damage in peripheral lymphocytes of workers occupationally exposed to EMFs in electric transformer and distribution stations. In conclusion, our findings suggest that EMFs possess genotoxic capability, as measured by CA and MN assays; CA analysis appeared more sensitive than other cytogenetic end-points. It can be concluded that chronic occupational exposure to EMFs may lead to an increased risk of genetic damage among electrical workers.

Item Type:Conference Paper (UNSPECIFIED)
Uncontrolled Keywords:Chromosome aberration , Electromagnetic field exposure , Micronucleus , Occupational hazard
Subjects:Q Science > Q Science (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:SCHOOL > School of Medicine
SCHOOL > Biotechnology Research Institute (BRI)
ID Code:5995
Deposited By:IR Admin
Deposited On:17 May 2013 10:41
Last Modified:18 May 2015 11:30

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