Acid neutralization capacity and characteristics of antacid products

Pusparani Sagadavan, (2007) Acid neutralization capacity and characteristics of antacid products. Universiti Malaysia Sabah. (Unpublished)

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Abstract

Six brands of antacids, including three for tablet and three for liquid samples were analyzed for their acid neutralization capacity (ANC) and acid neutralization rate. The acid Neutralization capacity was determined according to back titration method. Excess amount of HCI was reacted with an antacid sample and the HCI remaining after the antacid neutralization reaction occurs was titrated by standardized NaOH solution to a phenolphthalein endpoint. Results obtained showed the ANC of the tablet and liquid samples ranged 0.72 - 1.66 moles/tablet and 0.66 - 1.65 moles/mL, respectively. Results obtained for the potentiometric titration showed Povil can neutralize more of HCI acid where the magnitude in pH decrease for Povil is less than Maalox-Plus and Actal. For liquid antacids, Mixture Magnesium Trisilicate (MMT) can neutralize more of HCI acid followed by Alucid and Dhalumag. Maalox-Plus showed the highest neutralization rate followed by Actal and Povil, both in the tablet and powder form. For liquid antacids, MMT showed the fastest rate followed by Alucid and Dhalumag. Comparatively, antacids in the form of liquid showed higher rate of neutralization compared to powder and tablet antacids.

Item Type: Academic Exercise
Uncontrolled Keywords: antacid, acid neutralization capacity, acid neutralization rate, titration method, pH, Mixture Magnesium Trisilicate, Maalox-Plus, liquid, neutralization
Subjects: Q Science > QD Chemistry
Divisions: SCHOOL > School of Science and Technology
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 07 Jan 2014 03:10
Last Modified: 10 Oct 2017 08:04
URI: http://eprints.ums.edu.my/id/eprint/7977

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