Structural elucidation and biological activities of halogenated secondary metabolites of Laurencia similis and Laurencia nangii collected from the waters of Sabah

Leung, Eleanor Wai Wai (2004) Structural elucidation and biological activities of halogenated secondary metabolites of Laurencia similis and Laurencia nangii collected from the waters of Sabah. Universiti Malaysia Sabah. (Unpublished)

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Abstract

Laurencia similis and Laurencia nangii are known as macroalgae belonging to the Rhodophyta division or Red algae. Laurencia similis is unique in producing 2 novel polybrominated indoles compounds. The two compounds are I-methyl 2,3,5,6-tetrabromoindole (1) and 2,3,5,6-tetrabromoindole (2) in which their structures were deduced on the basis of spectroscopic evidence. Laurencia nangii from Langkayan Island produces three compounds which are Palisadin A and two compounds which are known to be C 15-acetogenins compounds. The yield of Compound 1 was 29% whilst percentage of Compound 2 was 30% which are obtained from Laurencia similis. The yield of Palisadin A was 2% and the two C�₅-Acetogenin compounds were 6% and 2% respectively. The eleven bacteria species used were Escherichia coli, Pseudomonas aeurogenes, Enterococcus faecalis, Salmonella sp. ,Proteus mirabilis, Clostridium cellobioparum, Clostridium sordelli, Clostridium novyi, Proteus vulgaris, Vibro anginolyticus dan Vibro parahaemolyticus. Out of the eleven bacteria, six are pathogenic bacteria whilst the rest is environmental bacteria. Compound 1 (1-methyl 2,3,5,6-tetrabromoindole) and Compound 2 (2,3,5,6-tetrabromoindole) of Laurencia similis showed no inhibition against the five pathogenic bacteria. Antibacterial test had tested on the two compounds from Laurencia similis. However, only Compound 2 showed 65% of inhibition against four environmental bacteria, while Compound 1 showed 40% activity against two environment bacteria that are Clostridium novyi and Vibrio anginolyticus. Based on this study and past study, compounds of Laurencia similis have the potential of becoming antibiotics.

Item Type: Academic Exercise
Uncontrolled Keywords: macroalgae, Laurencia similis, Laurencia nangii, bacteria species, compound, Palisadin A, C�₅-Acetogenin
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: SCHOOL > School of Science and Technology
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 20 Jan 2014 06:01
Last Modified: 11 Oct 2017 04:44
URI: http://eprints.ums.edu.my/id/eprint/8062

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