Determination of active compounds in analgesic formulations using HPLC

Teah, Yu Nuo (2008) Determination of active compounds in analgesic formulations using HPLC. Universiti Malaysia Sabah. (Unpublished)


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Non-narcotic analgesics act peripherally by blocking pain signals going to the brain or by interfering with the brain's interpretation of the signals, without producing anesthesia or loss of consciousness. This study attempted to analyse the presence of phenacetin, caffeine and acetyl salicylic acid in nine types of different analgesic formulation (Panadol Normal, Panadol Actifast, Panadol Muscle and Joint, Panadol Kids, Panadol Soluble, Bayer Aspirin, Alka-Seltzer, Disprin and G-Asp Tablet) using a reversed phase High-Performance Liquid Chromatography (HPLC). Separation was completed in < 6 min. The result of the analysis showed that the Bayer Aspirin, Alka- Seltzer, Disprin and G-Asp Tablet contained acetyl salicylic acid as the active compound with concentration of 181.31 mg/g, 15.84 mg/g, 63.87 mg/g, and 10.11 mg/g, respectively. Among the 4 types of tablets, Bayer Aspirin had the strongest analgesic strength since it contained the most amount of acetyl salicylic acid.

Item Type: Academic Exercise
Uncontrolled Keywords: High-Performance Liquid Chromatography (HPLC), analgesic formulation, Bayer Aspirin, active compound
Subjects: T Technology > TP Chemical technology
Divisions: SCHOOL > School of Science and Technology
Date Deposited: 10 Jul 2014 02:33
Last Modified: 12 Oct 2017 05:34

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