Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy

Maria Sydorovaa, and Lee, Mun Seng (2005) Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy. In: 3rd European-Vitreoretinal-Society Congress, 13-16 September 2003 , Sopron, Hungary.

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Official URL: http://dx.doi.org/10.1159/000086594

Abstract

Purposes: To confirm the role of vascular endothelial growth factor (VEGF) in the pathogenesis of proliferative diabetic retinopathy (PDR) and proliferative vitreoretinopathy (PVR) and to investigate the relationship between the level of VEGF in serum and its vitreal level in patients with either disease. Methods: Venous blood and vitreous of 18 patients with PDR, 15 patients with PVR and 20 patients forming a control group were collected during vitrectomy. The VEGF level was quantified by using ELISA methods in either serum or vitreous. Results: The VEGF level in serum and vitreous was similarly high in the case of PDR, but its level was only high in serum in the case of PVR. Discussion: PDR is closely linked with systemic diabetes mellitus whereas PVR is more localized. More selective systemic anti-VEGF medications with reduced side effects are required to treat PDR successfully. Copyright (C) 2005 S. Karger AG, Basel.

Item Type:Conference Paper (UNSPECIFIED)
Uncontrolled Keywords:Proliferative diabetic retinopathy, Proliferative vitreoretinopathy, Vascular endothelial growth factor
Subjects:R Medicine > RE Ophthalmology
Divisions:SCHOOL > School of Medicine
ID Code:971
Deposited By:IR Admin
Deposited On:18 Oct 2011 11:58
Last Modified:29 Dec 2014 16:15

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