Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction

Md. Ariful Alam and I. S. M. Zaidul and Kashif Ghafoor and Sahena Ferdosh and Md. Eaqub Ali and H. Mirhosseini and B. Y. Kamaruzzaman and Md Jahurul Haque Akanda and A. Khatib (2021) Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction. Separation Science and Technology, 52 (5). pp. 852-863. ISSN 1520-5754

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Abstract

Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC-Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity.

Item Type: Article
Uncontrolled Keywords: α-Glucosidase Inhibitory Activity , Antioxidant , Clincanthus nutans , Subcritical Carbon Dioxide Extraction
Subjects: Q Science > QD Chemistry
Q Science > QK Botany
Divisions: FACULTY > Faculty of Food Science and Nutrition
Depositing User: SAFRUDIN BIN DARUN -
Date Deposited: 30 Jun 2021 20:21
Last Modified: 30 Jun 2021 20:21
URI: http://eprints.ums.edu.my/id/eprint/27531

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