Samsidar Anwar (2010) Anti-quorum sensing activity of tropical plant spices. Universiti Malaysia Sabah. (Unpublished)
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Abstract
The development of resistance among bacterial to antibiotics is an obvious problem currently. It is recognised that Interruption of bacterial cell-cell communication termed as bacterial quorum sensing (QS) have been shown to attenuate the virulence of bacteria. This study hypothesized that tropical plant spices possess anti-QS compounds which can attenuate bacterial pathogenicity. To test this hypothesis, ethanolic and aqueous extracts of six plants were examined and screened for anti-QS activity using a biomonitor bacterial strain, Chromabacterium violaceum. Two ethanolic extracts showed QS inhibition: Cinnamomum verum (dnnamon) and Syzygium aromaticum (dove). Meanwhile, two aqueous extracts also showed QS inhibition: Elettaria cardamomum (cardamom) and Syzygium aromaticum (clove). Their effects on the QS system and virulence of pathogenic Pseudomonas aeruginosa were further examined through swarming motility and biofilm formation assay. Results obtained indicated that all extracts significantly inhibited bacteria swarming motility. The observation that there are ability of plant species to Inhibit QS related processes opens up an exciting potential new therapeutic alternative for the treatment of bacterial Infections.
| Item Type: | Academic Exercise |
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| Keyword: | antibiotics, bacterial, quorum sensing, tropical plant spices, ethanolic, aqueous extracts |
| Subjects: | ?? QR75-99.5_Bacteria ?? |
| Department: | SCHOOL > School of Science and Technology |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 02 Jun 2016 08:37 |
| Last Modified: | 30 Oct 2017 11:23 |
| URI: | https://eprints.ums.edu.my/id/eprint/13301 |
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