Syamim Johan and Allim Khairuddin and Asyraf Mohd Zuki and Wei Woon Teng and Firdaus Hayati and Aung Mra and Nornazirah Azizan (2021) Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma. Clinical Journal of Gastroenterology.
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Abstract
Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments.
| Item Type: | Article |
|---|---|
| Keyword: | gastrointestinal neoplasm, non-hodgkin lymphoma, plasmablastic lymphoma |
| Subjects: | R Medicine > R Medicine (General) |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | DG MASNIAH AHMAD - |
| Date Deposited: | 12 Apr 2021 10:53 |
| Last Modified: | 12 Apr 2021 10:53 |
| URI: | https://eprints.ums.edu.my/id/eprint/26723 |
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