Anu Bahl and Sanjay Madhukar Jachak and Kishneth Palaniveloo and Tulasiramanan R. Ramachandram and Charles Santhanaraju Vairappan and Harish Kumar Chopra (2014) 2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475
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Abstract
A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2 Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.
| Item Type: | Article |
|---|---|
| Keyword: | 2-Acetoxyverecynarmin C; Briarane diterpenoid; COX-1; COX-2; Pennatula aculeata |
| Subjects: | Q Science > QD Chemistry |
| Depositing User: | MDM FAUZIAH MATSIN |
| Date Deposited: | 15 Dec 2014 15:21 |
| Last Modified: | 31 Jul 2021 16:18 |
| URI: | https://eprints.ums.edu.my/id/eprint/10150 |
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