Lai, Fong Chan and Choon, Leng Eu and Shean, Yih Soh and Thambu Maniam and Zuri Shahidii Kadir and Chong, Benedict Tak Wai and Loo, Jiann Lin and Shalisah Sharip and Wong, Vincent Choong Wai and Tsui, Huei Loo and Yin, Ping Ng and David A. Kahn Is Ketamine the Future Clozapine for Depression? A Case Series and Literature Review on Maintenance Ketamine in Treatment-resistant Depression With Suicidal Behavior. Journal of Psychiatric Practice, 24 (4). pp. 279-291. ISSN 1528-1145
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Abstract
Ketamine has shown effectiveness as a rapid-acting antidepressant with antisuicidal effects in terms of reduction of suicidal ideation in the short term. However, the evidence for long-term maintenance ketamine therapy for treatment-resistant depression (TRD) and suicidal behavior is limited. This case series (N=13) highlights the role of adjunctive serial maintenance ketamine infusions in restoring functionality in treatment-resistant unipolar and bipolar (mixed) depression with significant suicide risk and multiple comorbidities, including alcohol dependence. Two cases of TRD achieved functional remission with long-term maintenance ketamine treatment. The first case illustrates the potential synergistic interaction between ketamine and lamotrigine to achieve a sustained antidepressant response in the patient for 7 months. The second case may possibly be the longest reported case of maintenance ketamine therapy, with treatment continuing for 5 years to date. Ketamine treatment showed acute effectiveness in another 7 cases, especially in terms of reduction of suicidal ideation, albeit without significant long-term antidepressant effect. Factors that may contribute to lack of effectiveness of serial ketamine include inadequate mood stabilization in TRD in bipolar spectrum diagnoses, concomitant benzodiazepine use, complex comorbidities, and adverse effects such as significant hypertension and severe dissociation. Future systematic controlled studies are warranted to establish the efficacy and safety profile of long-term ketamine as maintenance therapy for TRD with suicidal behavior.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Maintenance ketamine, suicidal behavior, treatment-resistant unipolar/bipolar depression |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 10 Jul 2019 07:52 |
| Last Modified: | 10 Jul 2019 07:52 |
| URI: | https://eprints.ums.edu.my/id/eprint/22478 |
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