Phan, Chin Soon and Takashi Kamada and Toshiyuki Hamada and Charles Santhanaraju Vairappan (2018) Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. Records of Natural Products, 12 (6). pp. 643-647.
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Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. 1.pdf Download (639kB) | Preview |
Abstract
Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.
| Item Type: | Article |
|---|---|
| Keyword: | Borneo, sponge, sesterterpenes, adult T-cell leukemia |
| Subjects: | Q Science > QH Natural history Q Science > QH Natural history > QH301-705.5 Biology (General) |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 10 Jun 2020 15:29 |
| Last Modified: | 10 Jun 2020 15:29 |
| URI: | https://eprints.ums.edu.my/id/eprint/25502 |
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