Teppei, Kawahara and Yasuhiro, Kumaki and Takashi, Kamada and Takahiro, Ishii and Tatsufumi, Okino (2009) Absolute configuration of chlorosulfolipids from the chrysophyta Ochromonas danica. Journal of Organic Chemistry, 74 (16). pp. 6016-6024. ISSN 0022-3263
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Abstract
(Chemical Equation Presented) We isolated eight chlorosulfolipids (1-8) from the chrysophyta Ochromonas danica (IAM CS-2), including five new chlorosulfolipids (2-5, 8). The planar structures of all the compounds were elucidated by 1D and 2DNMR and ESI-MS/MS analyses.We determined the relative configuration of seven chlorosulfolipids (1-7), including the most commonly known chlorosulfolipid, 2,2,11,13,15,16-hexachlorodocosane-1,14-disulfate (1), by J-based configuration analysis (JBCA). The absolute configuration of each compound was determined using a modified Mosher's method after chemical degradation. 2,2,11,13,15,16-Hexachloro-14-docosanol-1-sulfate (2) was the most toxic to brine shrimp (Artemia salina) larvae (LC50 0.27 μg/mL). Compounds 1 and 4-8 were less toxic (LC50 2.2-6.9 μg/mL). Compound 3 was not toxic at 30 μg/mL. © 2009 American Chemical Society.
| Item Type: | Article |
|---|---|
| Keyword: | Absolute configuration, Artemia salina, Chemical degradation, Chemical equations, Configuration analysis, ESI-MS/MS, Mosher's method, Planar structure |
| Subjects: | Q Science > QD Chemistry > QD1-999 Chemistry > QD241-441 Organic chemistry |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 30 Mar 2011 12:28 |
| Last Modified: | 13 Oct 2017 11:23 |
| URI: | https://eprints.ums.edu.my/id/eprint/2603 |
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