Host and parasite immunopathogenesis of Malaria

Aye Aye Wynn and Ohnmar Myint and Thant Zin (2016) Host and parasite immunopathogenesis of Malaria. Journal of Denral and Medical Sciences (IOSR), 15 (3). pp. 134-138. ISSN 2279-0853

	Text Host and parasite immunopathogenesis of Malaria FULL TEXT.pdf Restricted to Registered users only Download (331kB) | Request a copy
	Text Host and parasite immunopathogenesis of Malaria ABSTRACT.pdf Download (58kB)

Abstract

Malaria is a major health problem in various parts of the world especially affecting the tropical countries. It affects the vital organs causing severe complicated malaria. Clinical syndromes like severe cerebral malaria, anaemia, coagulation abnormalities, respiratory distress and severe anaemia can increase the mortality of malaria infected cases. Variation in individual susceptibility and severity and type of clinical presentations of malaria raises the need for Study of both the parasite and host immune reactions as well as the contribution of inflammatory cytokines in malaria pathogenesis. This study explored the immunopathological basis and advances of severe malaria and their importance in pathogenesis of malaria and its complications. Previous and ongoing studies indicate that changes in endothelium during the sequestration of parasites in organs causes disruption of endothelial barrier function leading to serious effects of malaria. Parasite and host factors contribute to disturbance of cytokine regulation and escape of parasites from the immune system of the host. Disturbance of cytokine regulation and escape of parasites from the immune system of the host also contribute to pathogenesis of severe malaria. Immunopathological changes and dysregulation of cytokine production play central role in pathogenesis and disease severity in malaria.

Item Type:	Article
Keyword:	Malaria , Immunopathology , Host , Parasites
Subjects:	Q Science > QR Microbiology R Medicine > RA Public aspects of medicine
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	30 Jun 2021 20:32
Last Modified:	30 Jun 2021 20:32
URI:	https://eprints.ums.edu.my/id/eprint/27542

Actions (login required)

View Item