Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region

Yong Guang Teh and Nornazirah Azizan and Nur Atifah Mohd Naim and Chiak, Yot Ng and Ke, Juin Wong and Faizah Mohd Zaki (2021) Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region. [Experiment]

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Official URL: https://www.frontiersin.org/articles/10.3389/fped....

Abstract

Background: Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a new entity described in the 2016 World Health Organization (WHO) classification of brain tumors. While DL-GNT is predominantly an indolent tumor that affects young boys, high-grade DL-GNT is unusual and seldom reported in children.Case Presentation: In this report, we describe the challenges and pitfalls associated with diagnosing this high-grade variant in a tuberculosis-endemic region. We highlight the importance of identifying non-typical imaging findings, i.e., non-enhancing cystic lesions with high T2 signal along the leptomeningeal surface, that may expedite the diagnosis of this condition. Histopathologic correlations with MR spectroscopy findings are also discussed. Conclusion: We provide the first clinical imaging report of utilizing MR spectroscopy to distinguish DL-GNT from tuberculosis with histopathologic correlation.

Item Type:	Experiment
Keyword:	Diffuse leptomeningeal glioneuronal tumor , MR spectroscopy , Imaging , Tuberculosis , Meningitis
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens R Medicine > RJ Pediatrics > RJ1-570 Pediatrics
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	01 Apr 2022 14:52
Last Modified:	01 Apr 2022 14:52
URI:	https://eprints.ums.edu.my/id/eprint/32221

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