A case of potential inborn error of metabolism as a cause of young onset psychosis

Mohd Amiruddin Mohd Kassim and Pang, Nicholas Tze Ping and Muhammad Haniff Abdullah and Norharlina Bahar (2021) A case of potential inborn error of metabolism as a cause of young onset psychosis. Archives of Psychiatry Research, 57. pp. 203-208. ISSN 2671-1079 (P-ISSN) , 2671-2008 (E-ISSN)

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URL: https://hrcak.srce.hr/file/374355

Abstract

Introduction: Young onset psychosis has poor prognosis, and inborn errors of metabolism (IEM) can be easily missed. There is scarce information regarding IEM and young onset psychosis in Malaysia. Case Report: A 15-year-old Malay girl presented at the age of 8 years with a history of intellectual disability and neuro-regression, subsequently developing psychotic and obsessive-compulsive symptoms several years later. Organic workup revealed elevated lactate levels. Urine organic acid chromatogram revealed a moderate peak of lactate however most other investigations were normal. As MRI brain is normal and there are no neurological signs it appears less likely there is an underlying IEM-related aetiology for psychosis. Discussion: Various IEMs can be related to psychosis however the incidence is very low and quality of evidence is poor. Thus, any psychiatric presentation, particularly with suggestive clinical signs, should warrant an organic (including IEM) workup since these causes are potentially reversible with supplementation.

Item Type:	Article
Keyword:	Psychosis , Inborn error of metabolism , Organic
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	19 May 2022 09:23
Last Modified:	19 May 2022 09:23
URI:	https://eprints.ums.edu.my/id/eprint/32621

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