Cytokine (Il-10, il-6, tnf-a and tgf-ß1) gene polymorphisms in chronic hepatitis c virus infection among Malay male drug abusers

Che Ismail Che Noh and Imran Ahmad and Siti Suraiya and Nur Fadhlina Musa and Asma Abdullah Nurul and Abu Bakar Ruzilawati (2021) Cytokine (Il-10, il-6, tnf-a and tgf-ß1) gene polymorphisms in chronic hepatitis c virus infection among Malay male drug abusers. Biomedicines, 9 (1115). pp. 1-11. ISSN 2227-9059

	Text Cytokine (Il-10, il-6, tnf-a and tgf-ß1) gene polymorphisms in chronic hepatitis c virus infection among Malay male drug abusers.pdf Restricted to Registered users only Download (1MB) \| Request a copy
	Text Cytokine (Il-10, il-6, tnf-a and tgf-ß1) gene polymorphisms in chronic hepatitis c virus infection among Malay male drug abusers_ABSTRACT.pdf Download (89kB)

URL: https://www.mdpi.com/2227-9059/9/9/1115/htm

Abstract

Cytokines play an important role in modulating inflammation during viral infection, including hepatitis C virus (HCV) infection. Genetic polymorphisms of cytokines can alter the immune response against this infection. The objective of this study was to investigate the possible association between chronic hepatitis C virus infection susceptibility and cytokine gene polymorphism for interleukin-10 (IL-10) rs1800896 and rs1800871, interleukin 6 (IL-6) rs1800795, TNF-α rs1800629, and TGF-β1 rs1800471 in Malay male drug abusers. The study was conducted on 76 HCV-positive (HP) male drug abusers and 40 controls (HCV-negative male drug abusers). We found that there were significant differences in the frequencies of genotype for IL-10 rs1800871 (p = 0.0386) and at the allelic level for IL-10 rs1800896 A versus G allele (p = 0.0142) between the HP group and the control group. However, there were no significant differences in gene polymorphism in interleukin 6 rs1800795, TNF-α rs1800629 and TGF-β1 rs1800471. These findings suggest significant associations between gene polymorphism for IL-10 rs1800871, IL-10 rs1800896 (at the allelic level) and susceptibility to HCV infection among Malay male drug abusers.

Item Type:	Article
Keyword:	Cytokines . Gene polymorphism , Hepatitis C infection , Drug abusers , Malay male
Subjects:	H Social Sciences > HV Social pathology. Social and public welfare. Criminology > HV1-9960 Social pathology. Social and public welfare. Criminology > HV5800-5840 Drug habits. Drug abuse
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	12 Jul 2022 08:35
Last Modified:	12 Jul 2022 08:35
URI:	https://eprints.ums.edu.my/id/eprint/33081

Actions (login required)

View Item