Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities?

Anamul Hasan and Partha Biswas and Tohmina Afroze Bondhon and Khoshnur Jannat 1 and Tridib K. Paul and Alok K. Paul and Rownak Jahan and Veeranoot Nissapatorn and Tooba Mahboob and Polrat Wilairatana and Md Nazmul Hasan and Maria de Lourdes Pereira and Christophe Wiart and Mohammed Rahmatullah (2022) Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities? Molecules, 27. pp. 1-25. ISSN 1996-2022

	Text Can Artemisia .pdf Download (42kB)
	Text Can Artemisia 1.pdf Restricted to Registered users only Download (6MB)

Abstract

The focus of this roadmap is to evaluate the possible efficacy of Artemisia herba-alba Asso. (Asteraceae) for the treatment of COVID-19 and some of its symptoms and several comorbidities using a combination of in silico (molecular docking) studies, reported ethnic uses, and pharmacological activity studies of this plant. In this exploratory study, we show that various phytochemicals from Artemisia herba-alba can be useful against COVID-19 (in silico studies) and for its associated comorbidities. COVID-19 is a new disease, so reports of any therapeutic treatments against it (traditional or conventional) are scanty. On the other hand, we demonstrate, using Artemisia herba-alba as an example, that through a proper search and identification of medicinal plant(s) and their phytochemicals identification using secondary data (published reports) on the plant’s ethnic uses, phytochemical constituents, and pharmacological activities against COVID-19 comorbidities and symptoms coupled with the use of primary data obtained from in silico (molecular docking and molecular dynamics) studies on the binding of the selected plant’s phytochemicals (such as: rutin, 4,5-di-O-caffeoylquinic acid, and schaftoside) with various vital components of SARS-CoV-2, it may be possible to rapidly identify plants that are suitable for further research regarding therapeutic use against COVID-19 and its associated symptoms and comorbidities.

Item Type:	Article
Keyword:	COVID-19 , Comorbidity , Medicinal plants , Artemisia herba-alba , Molecular docking
Subjects:	R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA643-645 Disease (Communicable and noninfectious) and public health R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Department:	INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	03 Aug 2022 08:12
Last Modified:	03 Aug 2022 08:12
URI:	https://eprints.ums.edu.my/id/eprint/33650

Actions (login required)

View Item