Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia

Mohd Rohaizat Hassan and Nor Rumaizah MN and Mohd ‘Ammar IAZ and Mohd Nazrin J and Sharifah Azura S and Intan Kartina AK and Mohammad Saffree Jeffree and Syed Sharizman Syed Abdul Rahim and Mohd Firdaus Mohd Hayati and Hasanain FG (2022) Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia. Medicine & Health, 17. pp. 133-143. ISSN 2289-5728

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that causes severe morbidity, mortality and high medical expenses in many hospitals worldwide. The present study aimed to determine the prevalence of MRSA nosocomial infection, its associated factors, and its antimicrobial susceptibility pattern. This was a retrospective analysis of a database of Multidrug-Resistant Organism (MDRO) that was cultured from patients admitted to Hospital Canselor Tuanku Mukhriz (HCTM) over a period of 2 years (2018-2019). MRSA accounted for 23.6% of total MDRO isolates. The male gender had a higher risk for MRSA acquisition (p<0.05), while the most prevalent setting for MRSA was the orthopaedic ward (47.5%) followed by the medical ward (29.4%). The MRSA strains were significantly isolated from respiratory specimens (55.6%) followed by tissue (50.8%) and blood (27.8%). All MRSA isolates were resistant to penicillin G, oxacillin followed by ciprofloxacin (83.8%) erythromycin (71.5%) and clindamycin (53.5%). MRSA isolates were most susceptible to teicoplanin (99.7%), mupirocin (99.3%), co-trimoxazole (98.4%), rifampicin (97.8%), doxycycline (97.4%), linezolid (95.8%), gentamicin (93.9%) and fusidic acid (86.2%). The trend for MRSA’s antibiotic susceptibility in HCTM for the past 2 years (2018 to 2019) remains unchanged. Further research will be required to investigate the predictor of MRSA by clearly differentiating between MRSA infections and colonisations, hospital-acquired MRSA and community-acquired MRSA.

Item Type:	Article
Keyword:	Antibiotics , Antimicrobial drug resistance , Hospital-acquired infection , Methicillin resistant , Staphylococcus aureus
Subjects:	Q Science > QR Microbiology > QR1-502 Microbiology > QR75-99.5 Bacteria R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	15 Aug 2022 12:20
Last Modified:	15 Aug 2022 12:20
URI:	https://eprints.ums.edu.my/id/eprint/33763

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