Small Cell Neuroendocrine Tumour of Bladder: A Rare Entity and Review of the Literature

Muhamad Hud Muhamad Zin and Mohd Firdaus Mohd Hayati and Mohamed IzzadIshak and Siti Atiqah Abdul Halim and Isa Mohamed Rose and Fam, Xeng Inn and Zulkifli Md Zainuddin (2022) Small Cell Neuroendocrine Tumour of Bladder: A Rare Entity and Review of the Literature. Gazi Medical Journal, 33 (4). pp. 432-435. ISSN 2147-2092

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Abstract

Small cell neuroendocrine cancer of the bladder (SCNCB) is a rare tumor with highly aggressive characteristics and poor differentiation. It comprises less than 1% of bladder malignancy and usually diagnosed at an advanced stage. It is challenging to differentiate between SCNCB with other bladder tumors as they had a similar presentation. We presented a case of a 60-year-old gentleman who presented with painless hematuria and ultrasound and cystoscopy examination show mass on the right urinary bladder wall. Computed tomography revealed urinary bladder mass with invasion to the prostate. Histopathological examination after transurethral resection of bladder tumor display features consistent with small cell neuroendocrine carcinoma with muscularis propria invasion, positive for synaptophysin, chromogranin A and p53 in immunohistochemistry. The patient currently underwent neoadjuvant chemotherapy with Etoposide and cisplatin for 4-cycles. We, with this, presented a rare case of SCNCB, along with a discussion on the clinical presentation, histological characteristics, management, and prognosis.

Item Type: Article
Keyword: Neuroendocrine tumor , Bladder neoplasm , Small cell carcinoma , Histological variant
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department: FACULTY > Faculty of Medicine and Health Sciences
Depositing User: SAFRUDIN BIN DARUN -
Date Deposited: 29 Sep 2022 11:18
Last Modified: 29 Sep 2022 11:18
URI: https://eprints.ums.edu.my/id/eprint/34234

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