Solubility of Rosmarinic Acid in Supercritical Carbon Dioxide Extraction from Orthosiphon stamineus Leaves

Ahmad Hazim Abdul Aziz and Nor Faadila Mohd Idrus and Nicky Rahmana Putra and Mohd Azrie Awang and Zuhaili Idham and Hasmadi Mamat and Mohd Azizi Che Yunus (2022) Solubility of Rosmarinic Acid in Supercritical Carbon Dioxide Extraction from Orthosiphon stamineus Leaves. ChemEngineering, 6 (59). pp. 1-13. ISSN 2305-7084

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URL: https://www.mdpi.com/2305-7084/6/4/59

Abstract

Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessary. The present study used a green extraction method of supercritical carbon dioxide (SCCO2) extraction with the addition of ethanol as a modifier to objectively measure and correlate the solubility of RA from OS leaves. The solubility of RA in SCCO2 was determined using a dynamic extraction approach, and the solubility data were correlated using three density-based semi-empirical models developed by Chrastil, del Valle-Aguilera, and Gonzalez. Temperatures of 40, 60, and 80 ◦C and pressures of 10, 20, and 30 MPa were used in the experiments. The maximum RA solubility was found at 80 ◦C and 10 MPa with 2.004 mg of rosmarinic acid/L solvent. The RA solubility data correlated strongly with the three semi-empirical models with less than 10% AARD. Furthermore, the fastest RA extraction rate of 0.0061 mg/g min−1 was recorded at 80 ◦C and 10 MPa, and the correlation using the Patricelli model was in strong agreement with experimental results with less than 15% AARD.

Item Type:	Article
Keyword:	Solubility , Extraction rate , Supercritical carbon dioxide extraction , Orthosiphon stamineus , Rosmarinic acid
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry T Technology > TX Home economics > TX1-1110 Home economics > TX341-641 Nutrition. Foods and food supply
Department:	FACULTY > Faculty of Food Science and Nutrition
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	26 Sep 2022 11:34
Last Modified:	26 Sep 2022 11:34
URI:	https://eprints.ums.edu.my/id/eprint/34244

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