Effects of Andrographis paniculata on Carbon Tetrachloride (CCl4)-Mediated Renal Oxidative Damage in Rats

Mohammad Iqbal and Sang, Senty Vun and Koh, Pei Hoon (2023) Effects of Andrographis paniculata on Carbon Tetrachloride (CCl4)-Mediated Renal Oxidative Damage in Rats. Journal Of Tropical Biology And Conservation, 20. pp. 275-294. ISSN 1823-3920

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Abstract

A herbal medicinal plant known as Andrographis paniculata, or "hempedu bumi," is recognised for its numerous medicinal properties and role in promoting community health. Despite its widespread use, the potential nephroprotective effects and underlying mechanism of action of Andrographis paniculata remain unexplored. To address this gap, the present study aimed to investigate the nephroprotective effects of Andrographis paniculata against renal oxidative damage induced by carbon tetrachloride (CCl₄) in rats. Sprague-Dawley rats were pre-treated with Andrographis paniculata extract via gavage (100, 200, and 300 mg/kg b.w., respectively) once daily for 14 days, followed by two doses of CCl₄ (1.2 ml/kg b.w.) on the 13th and 14th days. After two weeks, rats were sacrificed, and a nephroprotective analysis was performed. CCl₄ administration at a dose of 1.2 ml/kg body weight resulted in oxidative stress in the renal system, as evidenced by elevated lipid peroxidation levels (TBARS). This oxidative stress was accompanied by a significant decrease in the activities of antioxidant enzymes and a depletion in the levels of reduced glutathione (p<0.05). Histopathological examination confirmed the impairment of renal function. Andrographis paniculata significantly mitigated the majority of these alterations. Based on our research, the nephroprotective advantages of Andrographis paniculata can be attributed to its ability to act as an antioxidant and scavenge free radicals.

Item Type:	Article
Keyword:	Oxidative stress, A. paniculate, Nephrotoxicity, Carbon tetrachloride
Subjects:	Q Science > QK Botany > QK1-989 Botany > QK1-474.5 General Including geographical distribution R Medicine > R Medicine (General) > R5-920 Medicine (General) > R5-130.5 General works
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	01 Feb 2024 15:37
Last Modified:	01 Feb 2024 15:37
URI:	https://eprints.ums.edu.my/id/eprint/38097

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